- 16 januari 2019
- vacaturenummer: 101117
Janssen Vaccines & Prevention, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, is dedicated to bringing meaningful innovation to global health. Our teams focus on the discovery, development, manufacture and marketing of vaccines and antibodies to protect people worldwide from infectious diseases.
In our organization, entrepreneurial people are working in a dynamic culture in which innovation and a 'can do' state of mind are the central points. In order to strengthen our team, we are continuously looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to Janssen. The offices of Janssen Vaccines & Prevention are located in Leiden.
For our department in Leiden we are looking for an enthusiastic
Analytical Development (Early Protein Characterization group)
The Early Protein Characterization group is part of the Analytical Development (AD) group and is focused on biochemical and biophysical characterization of protein-based vaccines by employing a broad range of state of the art analytical technologies. The Analytical Development group, which is part of the pharmaceutical and analytical department, has a pivotal role between the regulatory authorities, quality unit, and process development. The AD department works closely together with discovery and other process development groups and provides them with advanced analytical expertise.
We are looking for a motivated person who enjoys working in a multidisciplinary team. You will be working on protein analytics focused on:
• Applying analytical assays to comprehensively characterize peptide and/or proteins and identify process dependent modifications in their biophysical properties;
• Protein conformation, dynamics and Epitope mapping studies by Hydrogen-Deuterium Exchange Mass Spectrometry
• Formulation and stability studies to identify the optimal formulation for protein vaccine candidate;
• Addressing limitations in analytical assays – method development.
Methods include but are not limited to Chromatography (Size Exclusion, Reversed Phase, Affinity, etc), Asymmetric Flow Field-Flow Fractionation, Multi angle and Dynamic Light Scattering, Differential Scanning Calorimetry, Capillary Electrophoresis, Circular Dichroism, FTIR, Fluorescence and Mass Spectrometry.
Master/bachelor student in biophysical, (bio)chemical, biomedical, pharmaceutical or similar field
Experience with proteins and/or analytical assays
Independent and pragmatic
Fluent in English
We are looking for a motivated individual who enjoys working in a multidisciplinary team. You express yourself well in English, both verbal and in writing. You are flexible in work and behavior. You enjoy being part of a team, but you are also capable of working independently.
Uiteraard staat deze vacature open voor zowel mannen als vrouwen.